Two sample MR report
ANXA5_Monocyte (Mono) against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 6 | 0.0385136 | 0.0739314 | 0.6299191 |
| Weighted median | 6 | 0.0312948 | 0.0116472 | 0.0072120 |
| Inverse variance weighted | 6 | 0.0323963 | 0.0097538 | 0.0008956 |
| Simple mode | 6 | 0.0300645 | 0.0156710 | 0.1131501 |
| Weighted mode | 6 | 0.0306973 | 0.0154145 | 0.1030578 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.6696230 | 4 | 0.9550215 |
| Inverse variance weighted | 0.6765908 | 5 | 0.9842287 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0032658 | 0.0391235 | 0.9374857 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0001583 | 0 | TRUE | 0.2333613 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
